I recently upgraded my video card to a Sapphire Nitro+ Radeon RX 570 4GB. I am running Windows 10 Home 64-bit with all recent updates, I have 16 GB DDR5 RAM and a Ryzen 5 1600X cpu. Running the game I get the known error you can see here:

Although this is a known issue and the stickied thread implies that you can just click OK and play, MWO crashes, mainly during the first 10-20 seconds of each match. The error I get is this:

The only way I can play is by using the DirectX 9 setting, which seems to suffer from occasional stutter but is stable so far (more than 20 games played with no crashes).
I hope this helps some of the people who can't play at all.
Thanks and Happy New Year!