I guess if someone is so prejudiced (against an operating system, of all things ) that they'd rather **** around with Wine than run MWO properly, they can have at it. This game struggles to run decently in the best of times, on obscene hardware, but hey, as long as you're not on my team, I'll be happy to take advantage of the whopping 15fps you might claw out of a massively overclocked 5820K while you watch me trash your mech from your "superior" OS, and god help you if you're running anything lower end than that. There's a reason this game doesn't have a thriving Wine sub-community:
(This awesome game performance brought to you by: running the game on low, at 720P, prior to the great 12-man performance dump)
YEAH WINE! So awesome!
Sadly, unlike your mech, this thread will probably never die :/
Unfortunately, I can safely say that MWO will never see an official release on OS X.
That being said, I can also safely say that you should be able to run it just fine under a dual boot/Boot Camp scenario if your hardware meets the requirements.